Solid Phase Extraction of Olanzapine with Reverse Phase Sorbents Prior to UV and HPLC Analysis

Anna Jasińska Institute of Chemistry, University of Bialystok, Bialystok, PolandCorrespondence[email protected]

Barbara Starczewska Institute of Chemistry, University of Bialystok, Bialystok, Poland

Monika Polkowska Institute of Chemistry, University of Bialystok, Bialystok, Poland

Helena Puzanowska‐Tarasiewicz Institute of Chemistry, University of Bialystok, Bialystok, Poland

Abstract

A solid‐phase extraction (SPE) method for the sample clean‐up followed by a UV and reversed‐phase high performance liquid chromatography (HPLC) procedure for the assay of olanzapine (OLA) is reported. SPE was carried out using the octadecyl (C₁₈), cyclohexyl (C₆H₁₁) columns, which belong to the reverse phase sorbents and the SDB‐1 column, define as polymeric sorbent. The spiked albumin samples were used to examine the recoveries of olanzapine from the investigated sorbent materials. The volume of albumin samples was 500 µl. The best extraction recoveries were performed with C₁₈ cartridges and these varied between 99.0–100.5% and 98.5–104.0% prior to our UV and literature HPLC analysis, respectively.

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Solid Phase Extraction of Olanzapine with Reverse Phase Sorbents Prior to UV and HPLC Analysis

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Solid Phase Extraction of Olanzapine with Reverse Phase Sorbents Prior to UV and HPLC Analysis

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