Preparation of Adsorbents for the Removal of Endotoxin

Guanghui Hou The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin, China

Tao Liu The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin, China

Huiyan Wang The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin, China

Guoqi Fu The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin, China

Zhi Yuan The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin, China

Bin Liu Tianjin Medical College, Tianjin, China

Lanju Sun Nankai Hospital of Tianjin, Tianjin, China

Jie Fang Nankai Hospital of Tianjin, Tianjin, China

Donghua Li Nankai Hospital of Tianjin, Tianjin, China

Qi Qiu Nankai Hospital of Tianjin, Tianjin, China

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Abstract

By using the agar beads as the support, L-lysine as the ligand, three kinds of absorbents with different spacers for removal of endotoxin were prepared. The adsorption capacity of three adsorbents was compared. Among them, Ag3, with L-lysine ligand and hexamethylendiamine as the spacer, was the best in adsorption capacity and was selected for hemoperfusion on rabbits. The results showed the level of endotoxin in endotoxemia rabbit after hemoperfusion was near normal level. The clearance percentage of endotoxin was 73.6%

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Preparation of Adsorbents for the Removal of Endotoxin

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Preparation of Adsorbents for the Removal of Endotoxin

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