Abstract
Many countries have local guidelines on the management of subjects' lipid levels with and without pharmaceutical intervention. The statin class of drugs is the preferred class for reducing low density lipoprotein cholesterol (LDL-C). Different statins have different potencies and different dose ranges. It is of interest to simulate clinical trials in which subjects are titrated through the dose ranges of various statins in accordance with local guidelines, in order to estimate the proportion of subjects who reach treatment goal of LDL-C at any particular dose of any particular statin.
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