SYNTHESIS OF A MANNOTETRAOSE—THE REPEATING UNIT OF THE CELL-WALL MANNANS OF MICROSPORUM GYPSEUM AND RELATED SPECIES OF TRYCHOPHYTON

Abstract

A tetrasaccharide, α-D-mannopyranosyl-(1→2)-α-D-mannopyranosyl-(1→6)-α-D-mannopyranosyl-(1→6)-D-mannopyranose (1), the repeating unit of the cell-wall mannans of Microsporum gypseum and related species of Trychophyton, was synthesized using 6-O-acetyl-2,3,4-tri-O-benzoyl-α-D-mannopyranosyl trichloroacetimidate (5) and 2-O-acetyl-3,4,6-tri-O-benzoyl-α-D-mannopyranosyl trichloroacetimidate (13) as the glycosyl donors in “the inverse Schmidt” procedure.

ACKNOWLEDGMENTS

This work was supported by the Chinese Academy of Sciences (KJ952J₁ 510 and KIP-RCEES9904) and the National Natural Science Foundation of China (59973026 and 29905004). Mr. Linsen Heng is a visiting scholar from Da Xian Normal College, Si Chuan, P. R. China.