Cardiotoxicity Associated With Intentional Ziprasidone And Bupropion Overdose

Abstract

Background: Ziprasidone (Geodon^®) and bupropion (Wellbutrin^®) are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses. Case Report: A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and anti-dysrhythmic therapy, stabilizing to baseline by 80 hours post-ingestion. Conclusions: We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.