N‐Acetylcysteine for the Treatment of Clove Oil Induced Fulminant Hepatic Failure: Case Report and Review of the Literature

Jeffrey S. Eisen Department of Emergency Medicine, Queen's University, Kingston, Ontario, Canada; Ontario Regional Poison Information Centre, and Staff, Hospital for Sick Children, Toronto, Ontario, Canada

, B.Sc., M.D.,

Gideon Koren Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada; Ontario Regional Poison Information Centre, and Staff, Hospital for Sick Children, Toronto, Ontario, Canada

, M.D., F.R.C.P.C.,

David N. Juurlink Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Ontario Regional Poison Information Centre, and Staff, Hospital for Sick Children, Toronto, Ontario, Canada

, M.D., Ph.D., F.R.C.P.C. &

Vicky L. Ng Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada; Pediatric Academic Multi‐organ Transplant Program, Hospital for Sick Children, Toronto, Ontario, Canada

, M.D., F.R.C.P.C.

Abstract

We present a 3‐month‐old female who developed fulminant hepatic failure after ingesting less than 8 mL of clove oil. Initial treatment involved gastrointestinal decontamination, supportive measures, and admission to hospital. She subsequently developed fulminant hepatic failure and was treated with intravenous N‐acetylcysteine (N‐AC) according to a protocol used for acetaminophen poisoning. Over the next 72h her liver synthetic function and clinical status improved, and she made a complete recovery. Previous reported cases of clove oil toxicity and the potential role of N‐AC therapy are reviewed.

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N‐Acetylcysteine for the Treatment of Clove Oil Induced Fulminant Hepatic Failure: Case Report and Review of the Literature

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N‐Acetylcysteine for the Treatment of Clove Oil Induced Fulminant Hepatic Failure: Case Report and Review of the Literature

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