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Original

Long-Term Effects on the Intelligence of Children Treated for Acute Lymphoblastic Leukemia

, , M.D., , Ph.D., , M.D., , M.D., , M.D., , M.D., , M.D. & , Ph.D., M.D. show all
Pages 581-587 | Published online: 31 Jul 2001
 

Abstract

The purpose of this study was to investigate whether the intelligence quotient (IQ) in children treated for leukemia decreases in the years following whole brain irradiation. Twenty-seven leukemic children were assessed following a mean time lapse between radiotherapy and IQ measurement of 9 years. The IQ test used was the Hamburg Weschsler Intelligence Test for Adults. The IQ results did not differ significantly, p > 0.05, from the IQs of the general population. It was found that age and dose were not predictors of a decrease in IQ. The only predictor was time lapse between irradiation and IQ measurement, which we found to be indicative of an IQ decrease even after 9 years. Time lapse between irradiation is a useful predictor of IQ.

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