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Original

Hematopoietic Stem Cells

, M.D., , M.D. & , Ph.D.
Pages 124-138 | Published online: 22 Apr 2002
 

Abbreviations
BFU-E=

Erythrocyte Blast Forming Units

CD-…=

Cluster Designation-… (a unique cell surface epitope used for phenotyping cells)

CFU=

Colony Forming Unit (in vitro assay to culture and score for lineage directed proliferation of precursor cells)

CFU-G=

Colony Forming Unit Granulocyte Lineage

CFU-L=

Colony Forming Unit Lymphocyte Lineage

CFU-M=

Colony Forming Unit Macrophage Lineage

CFU-Meg=

Colony Forming Unit Megakaryocyte Lineage

CFU-Eo=

Colony Forming Unit Eosinophil Lineage

CFU-E=

Colony Forming Unit Erythroid Lineage

CFU-GM=

Colony Forming Unit for Granulocyte/Macrophage Lineage

CFU-GEMM=

Mixed Colony Forming Unit Granulocyte-Erythrocyte-Macrophage-Monocyte

CFU-HPP=

Colony Forming Unit with High Proliferative Potential (not lineage committed, primitive precursors)

CFU-S=

Synonym S-CFU Colony Forming Units Spleen (in vivo assay performed in mice to study HSC quality)

CFU-S8=

Spleen Colony Forming Units scored on day 8

CFU-S12=

Spleen Colony Forming Units scored on day 12

CRU=

Competitive Repopulating Unit (in vivo assay where different HSC compete for repopulation of a myeloablated mouse)

CSF=

Colony Stimulating Factors (proteins that stimulate lineage directed proliferation of precursor cells)

Flt3 Ligand=

(growth factor acting on very primitive HSC, may play a role in self maintenance and expansion of HSC)

EPO=

Erythropoietin (factor acting on mature red blood cell precursors)

G-CSF=

Granulocyte Colony Stimulating Factor (stimulates predominantly granulopoiesis with neutrophilia in vivo)

GM-CSF=

Granulocyte Macrophage Colony Stimulating Factor (broader spectrum of stimulatory action than G-CSF, stimulates neutrophil and macrophage proliferation and differentiation)

HSC=

Hematopoietic Stem Cell

IL-…=

Interleukin-…(class of at least 21 different cytokines with variable biological actions on HSC and immune cells)

LIF=

Leukemia Inhibitory Factor (factor with some stimulatory action on primitive HSC)

LTBMC=

Long Term Bone Marrow Culture (in vitro culture using either feeder cells or a cytokine cocktail to maintain HSC viability over several weeks)

LTC-IC=

Long Term Culture Initiating Cells (in vitro test to assess the quality of candidate HSC after prolonged exposure in LTBMC. Cells are assayed by their ability to form CFU)

LTRC=

Long Term Repopulating Cells (cells that can repopulate a myeloablated host for a prolonged period of time, e.g., mouse >6 months)

M-CSF=

Macrophage Colony Stimulating Factor (stimulates macrophage development)

MRA=

Marrow Repopulating Ability (the ability of HSC to reconstitute hematopoiesis of a myeloablated animal)

OSC=

Omnipotent Stem Cells (proposed to be the most primitive cell with the universal ability of self-renewal and differentiation into any mature tissue of the entire organism)

PHSC=

Pluripotent Hematopoietic Stem Cells (the most primitive cell of the blood/immune system with the ability of regenerating all blood elements throughout the lifespan of the organism)

SCF=

Stem Cell Factor (stimulating growth factor acting on very primitive HSC, may play a role in self-maintenance. Also known as mast cell growth factor, stimulates mast cell proliferation)

S-CFU=

Synonym CFU-S Colony Forming Units Spleen

TGF=

Transforming Growth Factors (α and β) (factors with both stimulating and inhibitory functions on hematopoiesis)

TPO=

Thrombopoietin (factor acting on megakaryocytic lineage)

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