Determination of the Stability Constants in Alkanol/α-Cyclodextrin Mixed System

Yoshihiro Saito College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashishi, Chiba, 274-8555, Japan

Kaname Hashizaki College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashishi, Chiba, 274-8555, Japan

Hiroyuki Taguchi College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashishi, Chiba, 274-8555, Japan

Kazuo Tomono College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashishi, Chiba, 274-8555, Japan

Hiroko Goto College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashishi, Chiba, 274-8555, Japan

Naotake Ogawa College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashishi, Chiba, 274-8555, Japan

Abstract

The simultaneous determination of the stability constants for inclusion of alkanols with α-cyclodextrin (α-CD) was investigated in a mixed alkanol system using static head-space gas chromatography (SHSGC). The 1:1 stability constants obtained were in fair agreement with those obtained previously using other methods. The time required for determination of the stability constant was markedly reduced using this simultaneous SHSGC method.

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Determination of the Stability Constants in Alkanol/α-Cyclodextrin Mixed System

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Determination of the Stability Constants in Alkanol/α-Cyclodextrin Mixed System

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