The Use of a Hydrophobic Matrix for the Sustained Release of a Highly Water Soluble Drug

Abstract

An experimental investigation into the use of a hydrophobic matrix to control the release of a highly water soluble drug was undertaken. Matrices consisting of hydrogenated vegetable oil and calcium sulfate with a 4% drug loading showed a sustained-release profile of up to 24 hr. The release mechanism from such matrices seemed to obey both root time kinetics and first-order behavior. Investigations showed that the effect of geometry had a significant effect on the drug release rate.

Key Words:

• Controlled release
• Geometry
• Hydrophobic matrix
• Release rate
• Shape