Studies of Ion-Exchange Resin Complex of Chloroquine Phosphate

Abstract

High-potency adsorbates of chloroquine phosphate (CQP) were prepared by the batch method using a polyacrylic acid ion-exchange resin. Taste evaluation of the adsorbates shows significant masking of the bitterness of the drug. The complex formation was complete at pH 6.0. Stability studies at 37°C, 45°C, and 60°C indicated that the complex was stable at all conditions for 1 month. In vitro release studies revealed complete drug elution from the complex at pH 1.2 and 2.0.

Key Words:

• Chloroquine phosphate
• Drug release
• Ion-exchange resin
• Stability
• Taste masking