Comparative Tablet and Rheological Properties of New Microcrystalline Cellulose: Direct Compression and Wet Granulation Methods

Abstract

The overall objective of this study was to compare the rheological properties and tablet characteristics of two new varieties of celluloses (Vivacel 101 and 102), recently produced and commercialized, with the classical varieties of celluloses (Avicel and Elcema). The results showed no significant differences in the rheological properties of Vivacel and Avicel, while significant differences were found between the two celluloses and Elcema. Furthermore, there were no statistically significant differences in the disintegration times and T_d values of Vivacel and Avicel. In conclusion, it was found that these new celluloses offer all the known advantages of Avicel.