Examination of the Polymorphism of Piroxicam in Connection with the Preparation of a New “Soft-Patch” Type Pharmaceutical Dosage Form

G. Csóka Semmelweis University of Medical Sciences, Pharmaceutical Institute, Högyes E. str. 7, Budapest, H-1092, Hungary

E. Balogh Semmelweis University of Medical Sciences, Pharmaceutical Institute, Högyes E. str. 7, Budapest, H-1092, Hungary

S. Marton Semmelweis University of Medical Sciences, Pharmaceutical Institute, Högyes E. str. 7, Budapest, H-1092, Hungary

E. Farkas Semmelweis University of Medical Sciences, Pharmaceutical Institute, Högyes E. str. 7, Budapest, H-1092, Hungary

I. Rácz Semmelweis University of Medical Sciences, Pharmaceutical Institute, Högyes E. str. 7, Budapest, H-1092, Hungary

Abstract

The influence of different solvents (propylene glycol, glycerol, ethanol), as well as different technological procedures (melting, rapid and slow cooling), on the formation of polymorphous piroxicam modifications was examined in the course of the elaboration of a “soft-patch” type of semisolid pharmaceutical dosage form. The thermodynamical behavior, some physicochemical properties (such as melting point, dissolution rate), and infrared (IR) spectrum of the formed (needle and cubic) crystal modifications were studied, and the possibilities of their formation and their avoidance were examined.

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Examination of the Polymorphism of Piroxicam in Connection with the Preparation of a New “Soft-Patch” Type Pharmaceutical Dosage Form

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Examination of the Polymorphism of Piroxicam in Connection with the Preparation of a New “Soft-Patch” Type Pharmaceutical Dosage Form

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