Stability and In Vitro Drug Release of Flurbiprofen-Loaded Poly-ε-Caprolactone Nanospheres

Abstract

The effects of temperature and two different initial pH (2.67 and 7.00) on poly-ε-caprolactone (PεCL) nanospheres loaded with flurbiprofen (FB) (aqueous suspensions) were studied to investigate their influence on the stability and physicochemical characteristics of these drug delivery systems. The drug release behavior was also studied. Release of the associated FB occurred very fast on high dilution in a buffered medium. The stability of the polymeric system depends on the temperature and the initial pH value; it is more degradable with the particles stored at 40°C with an initial pH value of 2.67.

Key Words:

• In vitro release
• Nanospheres
• Ocular drug delivery
• Poly-ε-caprolactone
• Stability
• Thermal methods