Study of Formulation Parameters by Factorial Design in Metoprolol Tartrate Matrix Systems

Abstract

The study of formulation parameters in hydrophilic matrices of metoprolol tartrate by 2³ factorial design was made. We compared the dissolution profiles of two hydrophilic polymers (hydroxypropylmethylcellulose and hydroxyethylcellulose) at high and low concentrations and in the presence or absence of an insoluble excipient (calcium hydrogen phosphate dihydrate). The results showed that the presence of an insoluble excipient influenced almost all of the dissolution parameters.

Key Words:

• Dissolution parameters
• Factorial design
• Hydrophilic matrix
• Metoprolol tartrate