Microwave-Vacuum Drying of Pharmaceutical Powders

Abstract

Due to their temperature sensitive nature, many pharmaceutical products are dried under vacuum to facilitate solvent evaporation at reduced temperatures. However, this necessitates long drying times and represents a processing bottleneck. Microwave heating of such materials at reduced pressures offers a more rapid method of moisture removal, without the risk of product damage. Within this study, the effect of vacuum on the rate of solvent evaporation was investigated, using a range of powders (pharmaceutical actives Paracetamol and Aspirin, and a range of bulk excipients) and solvents including water, ethanol, methanol, and acetone. In general, drying rate increased as system pressure decreased, however, the magnitude and duration was system specific. As expected, the diffusion coefficient decreased from the first to the second falling rate period, with the diffusivity in each drying period increasing with increased vacuum. The findings in this research have significant implications for drying operations in the pharmaceutical industry.

Keywords:

• Bulk excipients
• Critical moisture content
• Diffusivity
• Drying rate curve
• K-Values
• Pharmaceuticals
• Solvents
• Vacuum