HEMATOLOGICAL AND MOLECULAR ANALYSIS OF β-THALASSEMIA AND Hb LEPORE IN CAMPANIA, ITALY

Mara Ferrara Department of Pediatrics, Naples’ Second University, Naples, 80138, ItalyCorrespondence[email protected]

Sofia M.R. Matarese Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy

Matteo Francese Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy

Barbara Borrelli Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy

Lina Coppola Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy

Antonietta Coppola Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy

Luigi Esposito Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy

show all

Abstract

This epidemiological study was based on a hematological and a molecular analysis of 310 heterozygous β thalassemic and 75 carriers of Hb Lepore out of 3,000 microcythemic subjects from the Campania region of Italy. The molecular analysis of β chains and the δβ hybrid gene has shown different β chain defects, but only the Hb Lepore-Boston-Washington type in association with haplotypes I and V. The prevalence and distribution of these molecular defects in Campania show that they are linked to historical events and to the geographical characteristics of this region.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

HEMATOLOGICAL AND MOLECULAR ANALYSIS OF β-THALASSEMIA AND Hb LEPORE IN CAMPANIA, ITALY

Information for

Open access

Opportunities

Help and information

HEMATOLOGICAL AND MOLECULAR ANALYSIS OF β-THALASSEMIA AND Hb LEPORE IN CAMPANIA, ITALY

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature