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Hemoglobin
international journal for hemoglobin research
Volume 26, 2002 - Issue 2
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Original

MODIFICATION IN THE FREQUENCY OF Hb C AND Hb S IN BURKINA FASO: AN INFLUENCE OF MIGRATORY FLUXES AND IMPROVEMENT OF PATIENT HEALTH CARE

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Pages 113-120 | Received 16 Jul 2001, Published online: 07 Jul 2009
 

Abstract

The incidence of hemoglobinopathies (Hb C and Hb S) is relatively high in West Africa. In order to calculate the gene frequency of these hemoglobinopathies, 6619 students from 23 local schools in Ouagadougou, Burkina Faso, West Africa, and 2582 individuals living in five villages near Ouagadougou, all situated in Savanna, were studied. As expected, the gene frequency in the city schools was 0.111 for the βC gene and 0.051 for the βS gene; in the five villages it was 0.122 for the βC gene and 0.047 for the βS gene. This data is somewhat different from that published in a previous study by Labie et al.Citation in the humid Savanna region, that showed a higher prevalence of βC (0.14) than βS (0.03), and is in contrast to data from the arid Sahel region that showed a higher prevalence of βS (0.1) compared to βC (0.05). The higher rate of βS and lower rate of βC in students in Ouagadougou, and in the individuals living in the five villages near Ouagadougou, suggest the possible influence of migratory fluxes of the βS gene from the country region of Sahel. The dramatic increase in the prevalence of Hb SS patients, not reported in the study of Labie et al.,Citation may be the result of reduced mortality due to environmental change. In addition, the improved health conditions of Hb SC and the increased life expectancy of Hb SS, may also have facilitated the increase of the βS gene and the focus on secondary prevention for the control of correlated diseases.

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