β‐Globin Gene Cluster Haplotypes Linked to the β^S Gene in Western India

Malay B. Mukherjee Institute of Immunohaematology (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India

Reema R. Surve Institute of Immunohaematology (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India

Raman R. Gangakhedkar National AIDS Research Institute, Pune, India

Kanjaksha Ghosh Institute of Immunohaematology (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India

Roshan B. Colah Institute of Immunohaematology (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India

Dipika Mohanty Institute of Immunohaematology (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India

Abstract

The present survey, which involves 70 sickle cell anemia patients from Gujarat and Maharashtra revealed a high prevalence of the typical Arab‐Indian haplotype (91.5 %). Six atypical haplotypes, including a Cameroon one were also found. Correlation of these various haplotypes with HbF expression was studied.

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β‐Globin Gene Cluster Haplotypes Linked to the β^S Gene in Western India

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β‐Globin Gene Cluster Haplotypes Linked to the βS Gene in Western India

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β‐Globin Gene Cluster Haplotypes Linked to the β^S Gene in Western India