Two New δ-Globin Mutations: Hb A₂-Ninive [δ133(H11)Val → Ala] and A δ⁺-Thalassemia Mutation [− 31 (A → G)] in the Tata Box of the δ-Globin Gene

Abstract

Two new δ-globin gene mutations have been detected: one leads to a fairly stable Hb A₂ variant differing electrophoretically only minimally from normal Hb A₂, and the second causes a δ⁺-thalassemia (thal) phenotype.

• Hb A₂ variant
• δ⁺-Thalassemia (thal)
• Carrier screening