Salidroside from Rhodiola sachalinensis Protects Neuronal PC12 Cells Against Cytotoxicity Induced by Amyloid‐β

S. I. Jang Department of Microbiology and Immunology, Wonkwang University School of Medicine, 344‐2 Shinyong‐Dong, Iksan, Chonbuk, 570‐749, South Korea

H. O. Pae Medicinal Resources Research Center of Wonkwang University, Iksan, Chonbuk, 570‐749, South Korea

B. M. Choi Medicinal Resources Research Center of Wonkwang University, Iksan, Chonbuk, 570‐749, South Korea

G. S. Oh Medicinal Resources Research Center of Wonkwang University, Iksan, Chonbuk, 570‐749, South Korea

S. Jeong Medicinal Resources Research Center of Wonkwang University, Iksan, Chonbuk, 570‐749, South Korea

H. J. Lee Department of Food Evaluation, Korea Food and Drug Administration, Seoul, South Korea

H. Y. Kim Department of Food Evaluation, Korea Food and Drug Administration, Seoul, South Korea

K. J. Kang Department of Food Evaluation, Korea Food and Drug Administration, Seoul, South Korea

Y. G. Yun Medicinal Resources Research Center of Wonkwang University, Iksan, Chonbuk, 570‐749, South Korea

Y. C. Kim Medicinal Resources Research Center of Wonkwang University, Iksan, Chonbuk, 570‐749, South Korea

H. T. Chung Department of Microbiology and Immunology, Wonkwang University School of Medicine, 344‐2 Shinyong‐Dong, Iksan, Chonbuk, 570‐749, South Korea; Medicinal Resources Research Center of Wonkwang University, Iksan, Chonbuk, 570‐749, South Korea

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Abstract

The amyloid β‐peptide (Aβ)‐induced oxidative stress is a well‐established pathway of neuronal cell death in Alzheimer's disease (AD). Salidroside, one of the major compounds from the roots of Rhodiola species (Crassulaceae), was investigated in vitro for its cytoprotection against Aβ‐induced toxicity on rat neuronal PC12 cells. Salidroside significantly reduced Aβ‐induced cytotoxicity in a dose‐dependent manner. Salidroside also reduced Aβ‐mediated intracellular accumulation of reactive oxygen species and malondialdehyde (MDA), a product of lipid peroxides, by preventing Aβ‐induced decline of antioxidant enzyme activities. These results suggest that salidroside protects neuronal PC12 cells from Aβ‐induced cytotoxicity via its antioxidant pathway.

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Salidroside from Rhodiola sachalinensis Protects Neuronal PC12 Cells Against Cytotoxicity Induced by Amyloid‐β

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Salidroside from Rhodiola sachalinensis Protects Neuronal PC12 Cells Against Cytotoxicity Induced by Amyloid‐β

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