Effects of the Geiji‐Bokryung‐Hwan on Carrageenan‐Induced Inflammation in Mice and Cyclooxygenase‐2 in Hepatoma Cells of HepG2 and Hep3B

Won‐Hwan Park National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk, 780‐714, Korea; Department of Biochemistry, Molecular Biology and Diagnostics, Dongguk University COM, Sukjang‐Dong 707, Kyungju City, Kyungbuk, 780‐714, Korea

Shin‐Tak Joo National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk, 780‐714, Korea; Department of Biochemistry, Molecular Biology and Diagnostics, Dongguk University COM, Sukjang‐Dong 707, Kyungju City, Kyungbuk, 780‐714, Korea

Kwan‐Kyn Park Kidney Institute, Keimyung University, Daegu, Korea

Young‐chae Chang Kidney Institute, Keimyung University, Daegu, Korea

Prof. Cheorl‐Ho Kim National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk, 780‐714, Korea; Department of Biochemistry, Molecular Biology and Diagnostics, Dongguk University COM, Sukjang‐Dong 707, Kyungju City, Kyungbuk, 780‐714, Korea

Abstract

We investigated the effects of a Korean traditional prescription, Geiji‐Bokryung‐Hwan (GBH) consisting of five herbs of Cinnamomi Ramulus (Korean name Geiji), Poria cocos (Bokryung), Moutan Cortex Radicis (Modanpi), Paeoniae Radix (Jakyak) and Persicae Semen (Doin) on tumor growth‐inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Effects of the GBH extracts on carrageenan‐induced edema inflammation using female (C57BL/6XC3H) F1 (B6C3F1) mice and tumorigenesis were examined. Finally, cyclooxygenase metabolites were determined after extracts treatment. These data suggest that GBH extracts merits investigation as a potential cancer chemopreventive agent in humans.

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Effects of the Geiji‐Bokryung‐Hwan on Carrageenan‐Induced Inflammation in Mice and Cyclooxygenase‐2 in Hepatoma Cells of HepG2 and Hep3B

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Effects of the Geiji‐Bokryung‐Hwan on Carrageenan‐Induced Inflammation in Mice and Cyclooxygenase‐2 in Hepatoma Cells of HepG2 and Hep3B

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