Distinct Cytokine Release Profiles from Human Endothelial and THP-1 Macrophage-like Cells Exposed to Different Amphotericin B Formulations

Lloyd W. Turtinen Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA; Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, WI, 54702, USA

Lindsay A. Bremer Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA

David N. Prall Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA

Jenifer Schwartzhoff Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA

Scott C. Hartsel Department of Chemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA

Abstract

Amphotericin B(AmB) formulations, Fungizone, and Amphotec caused substantially greater proinflammatory cytokine release than AmBisome (L-AMB) and Abelcet in TPA differentiated THP-1 macrophages as determined by antibody based protein arrays. Lipopolysaccharide but not AmB induced significant pro-inflammatory cytokines in human endothelial cells.

Key Words :

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Distinct Cytokine Release Profiles from Human Endothelial and THP-1 Macrophage-like Cells Exposed to Different Amphotericin B Formulations

Information for

Open access

Opportunities

Help and information

Distinct Cytokine Release Profiles from Human Endothelial and THP-1 Macrophage-like Cells Exposed to Different Amphotericin B Formulations

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature