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Original Article

Allergic Bronchopulmonary Fungal Disease Caused by Saccharomyces cerevisiae

, M.D., , M.D. & , M.D.
Pages 223-228 | Published online: 26 Aug 2009
 

Abstract

We describe a patient who presented with dry cough, low‐grade fever, and focal patchy shadow of pulmonary infiltrates. Remarkably, the prospective etiological agent, Saccharomyces cerevisiae was purely and repeatedly cultured from her sputum. Allergic bronchopulmonary mycosis (ABPM) was diagnosed based on clinical, serological, and pathological criteria. Although the patient described here satisfied only three of the criteria, the conclusion that the allergic bronchopulmonary disease in our case was induced by S. cerevisiae was made based on the following evidence: 1) S. cerevisiae was repeatedly isolated from the patient's sputum, 2) anti‐S. cerevisiae antibody was detected in her serum, and 3) bronchoprovocation test to S. cerevisiae antigen was positive. We present here a case of allergic bronchopulmonary fungal disease caused by S. cerevisiae antigen.

Abbreviations
ABPM:=

allergic bronchopulmonary mycosis

S. cerevisiae:=

Saccharomyces cerevisiae

FVC:=

forced vital capacity

FEV1:=

forced expiratory volume in 1 second

BALF:=

bronchoalveolar lavage fluid

TBBB:=

transbronchial bronchial biopsy

P. janthinellum:=

Penicillium janthinellum

BDP:=

beclomethasone dipropionate

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