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Abstract
A method of producing local antibiotic effects by means of an iontophoretic technique using free silver ions has been evaluated in vitro and in vivo for more than two decades. The antibiotic properties of the technique have proved useful in both animal and human studies. In the course of determining the optimal clinical methodology for infected open wounds, a significant growth stimulation property resembling local tissue regeneration was noted. This has been traced to either the apparent production of dedifferentiation of normal mature cells or the stimulation of preexisting stem cells in the wound, resulting in the production of large numbers of progenitor cells. This process has now been studied in detail, and the results are presented herewith.