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CLINICAL STUDY

Statin Therapy Helps to Control Blood Pressure Levels in Hypertensive Dyslipidemic Patients

, M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D. & , M.D. show all
Pages 297-303 | Published online: 07 Jul 2009
 

Abstract

Aim. Aside from lowering lipid levels; statins improve endothelial function, decrease platelet aggregation, reduce procoagulant blood factors, and decrease vascular tone. This study was conducted to investigate the possible effect of atorvastatin on blood pressure (BP) in a group of hypertensive and dyslipidemic patients. Methods. Thirty-six hypertensive and dyslipidemic patients with inadequately controlled lipid levels by diet were treated with atorvastatin 20 mg/day for 8 weeks and compared with 24 patient matched controls treated with diet alone. The type and dosage of antihypertensive medications were not altered during statin therapy. Blood lipid profile including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride (TG) levels were noted at inclusion and after 8 weeks. Ambulatory BP monitoring (ABPM) was carried out at study entry and at the end of week eight. Results. A total of 49 patients (32 patients in the atorvastatin group and 17 patients in the control group) completed the 3-month follow-up period of observation. The ABPM studies indicated significant reductions in total average systolic BP, total average diastolic BP, total average mean BP, day average systolic BP, day average diastolic BP, night average systolic BP, night average diastolic BP, and night average mean BP levels in the atorvastatin group, whereas these reductions were not observed in the control group. Conclusion. Our results indicate that atorvastatin therapy significantly improves BP control in hyperlipidemic hypertensive patients. However, the effects of other statins on BP, as well as, the different dosages need to be further investigated.

ABBREVIATIONS
HL:=

Hyperlipidemia

TC:=

Total cholesterol

HDL:=

High density lipoprotein

LDL:=

Low density lipoprotein

TG:=

Triglyceride

TAVESIS:=

Total average systolic blood pressure

TADIAS:=

Total average diastolic blood pressure

TAVMABP:=

Total average mean blood pressure

DASBP:=

Day average systolic blood pressure

DADBP:=

Day average diastolic blood pressure

NASBP:=

Night average systolic blood pressure

NADBP:=

Night average diastolic blood pressure

NAMBP:=

Night average mean blood pressure

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