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Original Articles

ANALYSIS OF SYNTHETIC GASTROINTESTINAL DRUGS IN ADULTERATED TRADITIONAL CHINESE MEDICINES BY HPCE

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Pages 2009-2019 | Received 01 Jun 1999, Accepted 07 Oct 1999, Published online: 06 Feb 2007
 

Abstract

Six synthetic gastrointestinal drugs, cimetidine, homatropine, metoclopramide, pirenzepine, ranitidine, and scopolamine butylbromide, which can be found as adulterants in traditional Chinese medicines were assayed simultaneously, within 6 min., using high performance capillary electrophoresis. The electrolyte was a buffer solution containing 100 mM phosphate buffer (NaH2PO4/H3PO4, pH 2.5) and 5 % acetonitrile. Applied voltage was 20.5 kV and temperature was 30°C. 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride was used as an internal standard and the detector was set at 214 nm. The effects of buffer pH and acetonitrile concentration on separation are important. The relative standard deviations of these gastrointestinal drugs for intra-day and inter-day analyses were 0.78–2.15 % and 1.10–2.75 %, respectively. The recoveries of the synthetic drug adulterants in traditional Chinese medicinal formula ranged from 97.3 to 102.4 %.

Acknowledgments

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