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Abstract
Chromatographic RMw and log k'w parameters have been used as alternatives to the shake flask n-octanol/water partition coefficient method to study the lipophilic character of several known pyrimidinic nucleoside derivatives and two novel ones. The RM and log k' values were measured by means of reversed-phase thin-layer chromatography (RP-TLC) and reversed-phase high performance liquid chromatography (RP-HPLC) respectively. Good linear relationships were observed between log P values obtained from the classical shake flask method (log Po/w) and each one of those obtained by chromatographic techniques (log PRP-TLC and log PRP-HPLC) and by theoretical calculations using the CLOGP program (log PCLOGP). The RMw and log k'w values have proven to be reliable parameters for describing the lipophilic properties of this family of compounds.
ACKNOWLEDGMENTS
The authors thank the Consejo de Investigaciones de la Provincia de Córdoba (CONICOR), the Secretaria de Ciencia y Técnica de la Universidad Nacional de Córdoba (SECyT-UNC) and the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina, for financial support. M.I.M. and G.M. acknowledge receipt of a fellowship granted by SECyT-UNC and CONICOR, respectively.