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Original Articles

THE USE OF A POLYSACCHARIDE-BASED COLUMN ON MULTIMODAL ELUTION

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Pages 1029-1038 | Received 12 Apr 1999, Accepted 14 Sep 1999, Published online: 06 Feb 2007
 

Abstract

Amylose tris (3,5-dimethylphenylcarbamate) coated onto APS-Hypersil (5 μm particle size and 120 Å pore size) was used under normal, reversed-phase and polar-organic conditions for the enantioseparation of six racemates of different classes. The CSP was not altered when going from one mobile phase to another. All compounds were enantioresolved within the elution modes with excellent selectivity factor. The simultaneous analysis of metyrapol enantiomers and metyrapone on reversed-phase conditions and the separation of the enantiomers of omeprazole in human plasma in the polar-organic mode of elution are also described.

ACKNOWLEDGMENTS

We thank FAPESP and CNPq for financial support.

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