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Abstract
Normal-phase preparative HPLC was applied to the purification of nitrendipine and its dimethyl ester from raw materials. For each separation, the chromatographic conditions were optimized by adjusting the sample size to achieve an efficient purification with a yield of 99% in the shortest time. The contaminating impurities were removed in a single step by preparative chromatography. This work demonstrates how gram quantities of analytically pure materials can be conveniently obtained using preparative HPLC.
ACKNOWLEDGMENTS
The author wishes to thank Astur Pharma (Asturias, Spain) for their gift of nitrendipine and its dimethyl ester for this study, and Fernando Díaz for his helpful comments.