Advanced search
Publication Cover
Journal of Liquid Chromatography & Related Technologies Volume 25, 2002 - Issue 18
Submit an article Journal homepage
36
Views
15
CrossRef citations to date
0
Altmetric
Original Articles

MOLECULAR MODELING OF ENANTIOMERIC RESOLUTION OF METHYLPHENIDATE ON CELLULOSE TRISBENZOATE CHIRAL STATIONARY PHASE

Hassan Y. Aboul-Enein Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh, 11211, Saudi ArabiaCorrespondence[email protected]
,
Imran Ali Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh, 11211, Saudi Arabia
,
Michel Laguerre Institut Europeen de Chimie et de Biologie (IECB), Ecole Polytechnique, ENSCPB, 16 Avenue Pey-Berland, Pessac Cedex, 33607, France
&
Guy Felix ENSCPB, 16 Avenue Pey-Berland (B.P. 108), Talence, F-33402, France
Pages 2739-2748 | Received 16 Apr 2002, Accepted 08 Jun 2002, Published online: 19 Aug 2006
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

ABSTRACT

The enantiomeric resolution of (±)-threo methylphenidate (MPH) (Ritalin®) has been achieved on Chiralcel OB column using the mobile phase hexane–ethanol–methanol–trifluoroacetic acid (480 : 9.75 : 9.75 : 0.5, v/v/v/v), containing benzoic acid and phenol as mobile phase additives. Ultraviolet detection was carried out at 230 nm. Molecular modeling was carried out to explain the chiral resolution mechanism of MPH enantiomers.

ACKNOWLEDGMENT

The authors (I.A. and H.Y.A-E.) would like to thank the King Faisal Specialist Hospital and Research Center, Riyadh administration for their support for the Pharmaceutical Analysis Laboratory Research Program.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Separation and detection of cyproconazole enantiomers and its stereospecific recognition with chiral stationary phase by high-performance liquid chromatography
Source: Royal Society of Chemistry (RSC)
Enantio-separation by chromatography and capillary electrophoresis
Source: Wiley
Enantiomeric resolution and simulation studies of four enantiomers of 5-bromo-3-ethyl-3-(4-nitrophenyl)-piperidine-2,6-dione on a Chiralpak IA column
Source: Royal Society of Chemistry (RSC)
Enantioseparation using carboxymethyl-6-(4-methoxybenzylamino)-β-cyclodextrin as a chiral selector by capillary electrophoresis and molecular modeling study of the recognition mechanism
Source: Royal Society of Chemistry (RSC)

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.