Separate Determination of Rate Constants from Reversible Reactions in a Chromatographic Column and Eluent Using Empirical Peak Shape Equations

Jana Lange Institute of Chemistry and Biochemistry, University of Greifswald, Soldmannstrasse 23, D-17489, Greifswald, Germany

Detlef Haberland Institute of Chemistry and Biochemistry, University of Greifswald, Soldmannstrasse 23, D-17489, Greifswald, Germany

Richard Thede Institute of Chemistry and Biochemistry, University of Greifswald, Soldmannstrasse 23, D-17489, Greifswald, GermanyCorrespondence[email protected]

Abstract

A new mathematical‐analytical equation is derived for fitting purposes in the determination of mobile phase rate constants of enantiomerization from liquid chromatographic reactor experiments with a recycling of the internal chromatogram via an empty capillary. The equation was successfully tested with results from numerical calculations, as well as results from the on‐column enantiomerization of oxazepam.

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Acknowledgment

The authors gratefully acknowledge financial support from the Deutsche Forschungsgemeinschaft (Proj. HA 2238/3‐1).

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Separate Determination of Rate Constants from Reversible Reactions in a Chromatographic Column and Eluent Using Empirical Peak Shape Equations

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Separate Determination of Rate Constants from Reversible Reactions in a Chromatographic Column and Eluent Using Empirical Peak Shape Equations

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