Purification of HTOS Libraries by Supercritical Fluid Chromatography

Jill Hochlowski Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USACorrespondence[email protected]

Jeff Olson Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA

Jeff Pan Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA

Daryl Sauer Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA

Philip Searle Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA

Thomas Sowin Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA

Abstract

A commercially available preparative scale supercritical fluid chromatography (SFC) system has been customized and applied to the purification of high throughput organic synthesis (HTOS) libraries. Pilot reactions allow the triage between HPLC and SFC as the most appropriate purification technique, and when applicable, SFC has been proven to offer advantages in terms of decreased purification and sample dry‐down time and purification capabilities, somewhat complementary to HPLC. Standardized chemistry‐specific SFC methods have been determined and HTOS pilot reactions allow refinement of these standard methods to optimal conditions for a specific library core.

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Purification of HTOS Libraries by Supercritical Fluid Chromatography

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Purification of HTOS Libraries by Supercritical Fluid Chromatography

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