Application of a Polymeric Solid Phase Extraction for the Analysis of Sulfonamides in Milk by LC/MS

Dal‐Ho Kim Organic Analysis Laboratory, Division of Chemical Metrology and Materials Evaluation, Korea Research Institute of Standards and Science, Yusong, Daejon, 305‐600, Republic of KoreaCorrespondence[email protected]

Jong Oh Choi Organic Analysis Laboratory, Division of Chemical Metrology and Materials Evaluation, Korea Research Institute of Standards and Science, Yusong, Daejon, 305‐600, Republic of Korea

Jinseog Kim Organic Analysis Laboratory, Division of Chemical Metrology and Materials Evaluation, Korea Research Institute of Standards and Science, Yusong, Daejon, 305‐600, Republic of Korea

Dai Woon Lee Department of Chemistry, Yonsei University, Seoul, Republic of Korea

Abstract

A simple clean up method for sulfonamides in milk, using a solvent extraction and unprecedented solid phase extraction (SPE) was studied. The effects of solid phase's type, solvent's type, and sample's pH on the extraction of sulfonamids were compared. Sample extracts were simply cleaned up and enriched by SPE on LiChrolut EN (ethylvinylbenzene–divinylbenzene‐copolymer). Liquid chromatography/atmospheric pressure chemical ionization‐mass spectrometry (LC/APCI‐MS) was used for the determination of sulfonamides. Milk samples, spiked with 8.2 ng/mL of sulfamethazine (SMZ), were assayed with a relative standard deviation (RSD) of 2.8% using isotope labeled internal standards.

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Application of a Polymeric Solid Phase Extraction for the Analysis of Sulfonamides in Milk by LC/MS

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Application of a Polymeric Solid Phase Extraction for the Analysis of Sulfonamides in Milk by LC/MS

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