HPLC Enantioseparation of Novel Chiral Tetrahedral Heterometal Clusters on a Cellulose tris‐(3,5‐Dimethylphenylcarbamate) CSP

Abstract

A series of novel tetrahedral heterometal cluster enantiomers have been separated on cellulose tris‐(3,5‐dimethylphenylcarbamate) stationary phase by high performance liquid chromatography, using hexane as the mobile phase with various alcohols as modifiers. The chromatographic parameters, retention factors (k), separation factors (α), and resolution factors (Rs) of all solutes were presented. The influence of the mobile phase composition on the enantioselectivity has been discussed, and the effect of structural variation of the solutes on their enantioseparation was also investigated and compared.

Keywords:

• CSP
• Tetrahedral heterometal clusters
• Enantioseparation

Acknowledgment

The authors thank the Chinese Academy of Sciences for financial support under a “Hundreds of Talents” program to Yongmin Li.