High Efficiency Liquid and Super‐/Subcritical Fluid‐Based Enantiomeric Separations: An Overview

Abstract

This overview covers chiral separations using high‐performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis. This is not intended to be a comprehensive review of all papers published in these areas. Chiral selectors can be categorized into a few classes: i.e., macrocyclic chiral selectors, polymeric chiral selectors, π–π interaction chiral selectors, ligand exchange chiral selectors, and miscellaneous/hybrid chiral selectors. The focus of this work is to outline the basic principles, structural features, and usefulness of each class of molecules. The evolution and major developments within each class of chiral selectors will be examined as well.

Keywords:

• Chiral separations
• Chiral selectors
• Chiral stationary phases
• Liquid chromatography (LC)
• Supercritical fluid chromatography (SFC)
• Capillary electrophoresis (CE)
• Capillary electrochromatography (CEC)
• Enantiomers

Acknowledgments

Support of this work by the National Institutes of Health (NIH 5RO1GM53825‐08) is gratefully acknowledged.