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Abstract
Lipophilicity is one of the properties, which influences the partition of a substance in biological media. The reversed‐phase high performance liquid chromatography (RP‐HPLC) capacity factors k of 27 2‐benzylsulfanyl derivatives of benzothiazole, newly synthesized as potential antituberculous drugs, were determined on a C18 stationary phase with methanol–water as the mobile phase, using UV detection. The measured log k values were compared with the log P values obtained by means of mathematical methods. High correlation was found between log P and log k values.
Acknowledgment
This work was supported by the Ministry of Education of the Czech Republic (Research Plans No. 111600001).