Planar Chromatography for New Quinazoline Derivatives

Abstract

The quinazoline derivatives (1–6) are potential antitumour preparations. The selectivity of the TLC parameters of six new quinazoline derivatives (1–6) has been investigated on silica gel 60 F 254. Optimisation of the retention and efficiency of these compounds was performed by changing the mixture of eluents and the concentration of modifier in organic diluent (v/v). Chromatograms were developed in the DS chamber and the substances were detected using UV light (λ 254 nm). The best separation parameters for compounds 1–3 were obtained with chloroform:ethyl acetate [5% (v/v)] as a mobile phase and for compounds 4–6 with ethyl acetate:acetonitrile [65% (v/v)] as a mobile phase.

Keywords:

• TLC
• Quinazoline
• 1,2‐Dihydroquinazoline N³‐oxides
• Silica

Acknowledgment

Analytical research is supported by Medical University of Łódź, Poland (grant no. 507 13 028).