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Abstract
A simple and rapid densitometric method has been developed for determination of allylestrenol in tablets. After extracting the samples with 96% ethanol, the solutions were spotted on pre‐coated silica gel TLC plates, which were eluted with a mixture of n‐hexane–ethyl acetate–dichloromethane (9.0:2.0:0.2, v/v). Quantitative evaluation was performed by measuring the absorbance reflectance of the allylestrenol spots at λ = 609 nm, after reaction with anisaldehyde–sulphuric acid reagent (5 min, 100°C). The TLC‐densitometry method is selective, precise, and accurate, and can be used for routine analysis of tablets in pharmaceutical industry quality control laboratories.
Acknowledgments
The authors are very grateful to Mr. Deddy Triono (Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia), and Mrs. Wiwin Farina Kartinasari (Bernofarm Pharmaceutical Company, Sidoarjo, Indonesia) for their very nice technical assistances.