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Journal of Liposome Research Volume 13, 2003 - Issue 3-4
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Research Article

The Interaction of DMSO with Model Membranes. I. Comparison of DMSO and d6-DMSO: A DSC and IR Investigation

Carla J. Long Department of Blood Research, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
,
Peter J. Hmel Department of Blood Research, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
,
Anthony Kennedy Department of Blood Research, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
,
John G. Quiles Department of Blood Research, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
,
Joseph Seelbaugh Department of Blood Research, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
&
Dr. Thomas J. Reid Department of Blood Research, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
Pages 249-257 | Published online: 24 Nov 2003
 
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Abstract

The effect of deuterated solvents on the main phase transition (Tm) temperature of large unilamellar vesicles (LUVs) of 1,2-dipalmitoyl phosphatidylcholine (DPPC) was examined by infrared spectroscopy and differential scanning calorimetry. There was no significant difference in the Tm, ΔH of the main transition, or cooperativity when water was replaced by deuterium oxide (D2O) in the preparation of the vesicles or when dimethylsulfoxide (DMSO) was replaced by hexadeutero-dimethylsulfoxide (d6-DMSO) in either D2O or water. These results provide the necessary advance for further structural, kinetic, and thermodynamic investigations of DMSO interactions with membranes and lipid vesicles.

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