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Journal of Macromolecular Science, Part A
Pure and Applied Chemistry
Volume 41, 2004 - Issue 10
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Original Articles

Studies on Formulation and In Vitro Evaluation of PVA/Chitosan Blend Films for Drug Delivery

K. Vidyalakshmi Department of Polymer Science and Technology, S.J. College of Engineering, Mysore, 570006, India
,
K. N. Rashmi Department of Polymer Science and Technology, S.J. College of Engineering, Mysore, 570006, India
,
T. M. Pramod Kumar Department of Pharmaceutics, J.S.S. College of Pharmacy, Mysore, 570015, India
&
Siddaramaiah Department of Polymer Science and Technology, S.J. College of Engineering, Mysore, 570006, IndiaCorrespondence[email protected]
Pages 1115-1122 | Received 01 Feb 2004, Accepted 01 Apr 2004, Published online: 22 Aug 2007
 
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Abstract

Films of polyvinyl alcohol (PVA) and chitosan blends, in different compositions, i.e., 100/0, 80/20, 60/40, 40/60, 20/80, and 0/100 (PVA/chitosan), have been prepared by a solution casting method, with and without incorporation of curcumin used as a model drug. The cast films contained glycerine (15% by weight of polymer) as a plasticizer; 1% glacial acetic acid, distilled water, and ethanol as solvents for chitosan, PVA, and curcumin, respectively. Mechanical properties, such as tensile strength, percentage elongation at break and barrier property [water vapor transmission rate (WVTR)] of the PVA/chitosan membranes were evaluated. The drug diffusion behavior of PVA/chitosan drug films in a buffer solution (pH 6.4) was established by an open glass diffusion cell.

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