UNDERSTANDING THE MODE OF ACTION OF L-NUCLEOSIDES AS ANTIVIRAL AGENTS: A MOLECULAR MODELING APPROACH

Abstract

Computer modeling studies have been performed on the several pairs of D- and L-nucleoside inhibitors with the HIV-1 RT model. Additionally, clinically important M184V mutation, which confers the viral resistance against 3TC and FTC, were studied by the same modeling system.

ACKNOWLEDGMENTS

This work was supported by grants from Public Health Service Research grants (AI32551), National Institutes of Health and The University of Georgia.