DNA SEQUENCE RECOGNITION BY NFκB p50 HOMODIMER: STRICT AND OBSCURE RECOGNITION SITES IN THE BINDING SEQUENCE

Atsushi Kittaka Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, 199-0195, Japan

Hiroaki Takayama Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, 199-0195, Japan

Masaaki Kurihara Division of Organic Chemistry, National Institute of Health Sciences, Setagaya-ku, Tokyo, 158-8501, Japan

Chikafumi Horii School of Pharmaceutical Sciences, Showa University, Shinagawa-ku, Tokyo, 142-8555, Japan

Hiromichi Tanaka School of Pharmaceutical Sciences, Showa University, Shinagawa-ku, Tokyo, 142-8555, Japan

Tadashi Miyasaka School of Pharmaceutical Sciences, Showa University, Shinagawa-ku, Tokyo, 142-8555, Japan

Jun-ichiro Inoue Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, 223-8522, Japan

show all

Abstract

5-Formyl- and 5-(formylmethyl)-2′-deoxyuridines are introduced into a κB site instead of thymidine(s) in order to understand target sequence specificity of NFκB. It was found that one thymidine in the κB site is particularly important for the sequence specific recognition by NF κB.

Acknowledgments

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

DNA SEQUENCE RECOGNITION BY NFκB p50 HOMODIMER: STRICT AND OBSCURE RECOGNITION SITES IN THE BINDING SEQUENCE

Information for

Open access

Opportunities

Help and information

DNA SEQUENCE RECOGNITION BY NFκB p50 HOMODIMER: STRICT AND OBSCURE RECOGNITION SITES IN THE BINDING SEQUENCE

Abstract

Acknowledgments

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature