NOVEL NUCLEOSIDES WITH VINYL FLUORIDE OR VINYL BROMIDE MOIETY AS OPEN-CHAIN ANALOGS OF NEPLANOCIN A

Myung-Hee Choi College of Pharmacy, Sookmyung Women's University, Seoul, 140-742, Korea

Chong-Kyo Lee Research Institute of Chemical Technology, Taejeon, 305-606, Korea

Lak Shin Jeong College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea

Moon Woo Chun College of Pharmacy, Seoul National University, Seoul, 151-742, Korea

Hee-Doo Kim College of Pharmacy, Sookmyung Women's University, Seoul, 140-742, Korea

Abstract

Novel nucleosides with vinyl fluoride and vinyl bromide were designed, synthesized and evaluated their antiviral activities against poliovirus, HSV, HIV, and HBV.

ACKNOWLEDGMENT

This research was supported by the grant from STEPI (99-N6-02-01-A-05), Korea.

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NOVEL NUCLEOSIDES WITH VINYL FLUORIDE OR VINYL BROMIDE MOIETY AS OPEN-CHAIN ANALOGS OF NEPLANOCIN A

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NOVEL NUCLEOSIDES WITH VINYL FLUORIDE OR VINYL BROMIDE MOIETY AS OPEN-CHAIN ANALOGS OF NEPLANOCIN A

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ACKNOWLEDGMENT

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