SYNTHESIS AND STUDY OF A NEW SERIES OF PHOSPHORAMIDATE DERIVATIVES AS MONONUCLEOTIDE PRODRUGS

Abstract

The synthesis and the study of new mononucleoside phosphoramidate diesters bearing S-acyl-2-thioethyl (SATE) groups and an alkylamino residue are reported. The studied compounds appear to be able to deliver the corresponding 5′-mononucleotide inside the cells, and could be considered as prototypes for a new kind of mononucleotide prodrugs (pronucleotides).

Acknowledgments