INCREASED RNA AFFINITY OF HNA ANALOGUES BY INTRODUCING ALKOXY SUBSTITUENTS AT THE C-1 OR C-3 POSITION

A. Van Aerschot Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven, 3000, Belgium

M. Meldgaard Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven, 3000, Belgium

F. Volders Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven, 3000, Belgium

G. Schepers Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven, 3000, Belgium

J. Rozenski Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven, 3000, Belgium

P. Herdewijn Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven, 3000, Belgium

Abstract

1,5-Anhydrohexitol nucleoside congeners with alkoxy substituents, were prepared, resulting in a further improvement of their RNA affinity and antisense potential.

ACKNOWLEDGMENT

This work was supported by a grant from the K.U. Leuven (GOA 97/11).

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INCREASED RNA AFFINITY OF HNA ANALOGUES BY INTRODUCING ALKOXY SUBSTITUENTS AT THE C-1 OR C-3 POSITION

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INCREASED RNA AFFINITY OF HNA ANALOGUES BY INTRODUCING ALKOXY SUBSTITUENTS AT THE C-1 OR C-3 POSITION

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ACKNOWLEDGMENT

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