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Abstract
Three different synthetic routes to the α-configured LNA thymine monomer starting from D-allose or D-arabinose were investigated. The introduction of one or four α-LNA monomers into α-DNA had a destabilizing effect on the duplexes. However, a fully modified α-LNA sequence displayed strong recognition of complementary RNA, but no transition with DNA.
ACKNOWLEDGMENT
The Danish Natural Science Research Council is thanked for financial support.