SYNTHESIS OF MODIFIED NUCLEOSIDE 5′-TRIPHOSPHATES FOR IN VITRO SELECTION OF CATALYTIC NUCLEIC ACIDS Citation[1]

Jasenka Matulic-Adamic Department of Chemistry & Biochemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301, U.S.A.

Andrew T. Daniher Department of Chemistry & Biochemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301, U.S.A.

Alexander Karpeisky Department of Chemistry & Biochemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301, U.S.A.

Peter Haeberli Department of Chemistry & Biochemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301, U.S.A.

David Sweedler Department of Chemistry & Biochemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301, U.S.A.

Leonid Beigelman Department of Chemistry & Biochemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301, U.S.A.

Abstract

2′-Modified pyrimidine nucleoside 5′-triphosphates comprising amino, imidazole and carboxylate functionality attached to the 5-position of the base were synthesized. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates.

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SYNTHESIS OF MODIFIED NUCLEOSIDE 5′-TRIPHOSPHATES FOR IN VITRO SELECTION OF CATALYTIC NUCLEIC ACIDS Citation[1]

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SYNTHESIS OF MODIFIED NUCLEOSIDE 5′-TRIPHOSPHATES FOR IN VITRO SELECTION OF CATALYTIC NUCLEIC ACIDS Citation[1]

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