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Abstract
6-azacytidine demonstrates activity against adenoviruses types 1, 2, 5. It inhibit synthesis of viral DNA and proteins. 6-AC shows antiherpetic and antiinfluenza action during experimental infection in mice. 6-AC is prospective for drug development as an antiviral substance with a wide spectrum of activity.
ACKNOWLEDGEMENTS
This study is partially supported by INTAS (Grant 97-31528, which dedicate to study of anticancer and antiviral properties of macrocyclic pyridinophanes). We are indebted to Organizing Committee of XIV International Roundtable on Nucleosides, Nucleotides and their Biological Applications for waiving of Registration Fee. Danyla Kryzhanovsky and Andrew Fedchuk are acknowledged for their technical assistance during preparation of this report.
