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Abstract
AegPNA and aepPNA monomeric units bearing the N7-guanine nucleobase as a substitute for C+ have been demonstrated to bind to a GC base-pair of a duplex in a pH-independent manner when placed in the third strand. The aepPNA backbone exerts a preference for binding in the antiparallel Hoogsteen mode over the parallel Hoogsteen mode.
ACKNOWLEDGMENTS
MD thanks CSIR, New Delhi for a fellowship. VAK and KNG acknowledge Department of Biotechnology, New Delhi, for a research grant.